|
PrometeoNetwork is extremely proud to announce the names of the winners of the 1st Edition of our PrometeoNetwork Travel Awards!
Dario Coletti
Title of the Abstract
Cytokines affect number and function of cell populations relevant to skeletal muscle homeostasis
Coletti D, Berardi E, Aulino P, Moresi V, Presterà A, Sassoon D, Adamo S
Summary of the Abstract
In this study we treated injured muscle with TNF to characterize the molecular mechanisms underlying the impairment of stem cell function in cachexia. TNF negatively affects the onset of regeneration as characterized by fibers with centrally located nuclei. TNF treatment markedly increases the number of cells showing caspase activation during regeneration, concomitantly with an inhibition in regeneration. Inhibition of caspase activity improves muscle regeneration either in the absence or presence of TNF, suggesting a non apoptotic role for this pathway in the myogenic program. Cells with caspase activity are localized in the interstitial compartment and identified by the expression of Stem Cell Antigen-1, CD34 and PW1. Consistently, PW1 was shown to control myogenic cell differentiation in vitro and fiber size in cachexia. Inhibition of PW1 activity blocks caspase activation and improves regeneration, pointing to PW1 as a potential target for gene therapy aimed to improve muscle regeneration.
Participant’s profile
https://www.within3.com/Members/Channels/User/?UID=5974
Marialuce Daniela De Blasi
Title of the Abstract
Listeria monocytogenes detection with Surface plasmon resonance and protein arrays
Marialuce Daniela De Blasi, Oscar Fernando D’Urso, Enrico Delorenzis, Roberto Rella, Maria Morea, Palmiro Poltronieri - CNR-ISPA e CNR-IMM, via Monteroni km 7, 73100 Lecce.
Summary of the Abstract
In this study the label-free SPR and QCM immunosensors and a protein array based method were compared for their application in bacterial detection using L. monocytogenes as a model pathogen. Surface plasmon resonance (SPR) and quartz crystal microbalance (QCM) techniques have been largely studied in label-free immunosensors for direct detection of bacteria. While use of DNA array for detection and identification of bacteria is largely documented, no studies are available on detection of bacteria by protein based array. Moreover there is a lack of comparative investigations on SPR, QCM and PA techniques.
Participant’s profile
https://www.within3.com/Members/Channels/User/?UID=6054
Kok Seong Lim
Title of the Abstract
Effect of SIRT1 Activation on Mitochondrial Diseases
Kok Seong Lim1, Akihiko Saitoh2, Robert K. Naviaux2,3, Tristan M. Stani2, Neurita G. Salva2, Paul S. Phillips4 , Peter J. Elliott5 and Richard H. Haas1,2
Departments of 1Neurosciences, 2Pediatrics, and 3Medicine, School of Medicine, University of California San Diego, La Jolla, California, USA; 4Scripps Mercy Clinical Research Center, Cardiology (Mer 74), Catheterization Laboratories, Scripps Mercy Hospital, San Diego, California, USA, 5Sirtris Pharmaceuticals, Cambridge, MA 02139, USA
Summary of the Abstract
Resveratrol may be useful treatment for mitochondrial disease as they have been reported to increase mitochondrial biogenesis. This effect could be clinically beneficial but there are concerns that mutation load might be increased in patients with mitochondrial DNA (mtDNA) mutations. In this study, we examined the effect of resveratrol on mutation using tissue samples obtained from patients with MELAS A3243G mutation and using myotubes derived from muscle biopsy of these patients. Our data suggest that the treatment using a low dose of resveratrol (in both human and cell culture) did not increase the mutation load in various tissues in patients with the MELAS mutation. These data were presented at the United Mitochondrial Disease Foundation (UMDF) Meeting held in Indianapolis, June 25-28, 2008. This research work is supported by the UMDF.
Participant’s profile
https://www.within3.com/Members/Channels/User/?UID=2379
Angela Russo
From left to right: Wofram Ruf, Angela Russo, JoAnn Trejo, Heidi Hamm and Athan Kuliopulos
Title of the Abstract
Caveolin-1 Differentially Regulates Protease-specific Signaling by Protease-activated Receptor-1
Angela Russo and JoAnn Trejo - Department of Pharmacology, School of Medicine, University of North Carolina at Chapel Hill, NC 27599-7365
Summary of the Abstract
Protease-activated receptor-1 (PAR1), a G protein-coupled receptor (GPCR), is expressed on cells in and around blood vessels and has important roles in hemostasis, thrombosis and inflammatory and proliferative responses associated with vascular injury. Several studies suggest that APC signals through PAR1 to induce Rac1 activation in a caveolin-1 dependent manner to regulate endothelial cell permeability and suggest a new mechanism for PAR1 functional selectivity through compartmentalization.
Participant’s profile
https://www.within3.com/Members/Channels/User/?UID=1334
|
